Methylation of the cyclic homolog of xanthine
Abstract
Alkylation of the cyclic homolog of xanthine in the methyl iodide-sodium hydride system as a function of the reagent-alkylating system ratio yields different products: for a 1∶3 ratio of reagents, a homolog of caffeine is formed, while for a 1∶2 ratio, a homolog of theobromine is formed. In contrast to xanthine, methylation of its cyclic homolog initially takes place at the imidazole ring and occurs in the sequence N(1), N(4), N(7).
How to Cite
Ivanov, É. I. Chem. Heterocycl. Compd. 1998, 34, 620. [Khim. Geterotsikl. Soedin. 1998, 34, 701.]
For this article in the English edition, see DOI https://doi.org/10.1007/BF02290949
