Synthesis of trifluoromethyl derivatives of pyrazolidine- and 2-pyrazoline-1-carboxamides and pyrazolidine- and 1-pyrazolinecarbothioamides

Abstract

The reactions of enones containing trifluoromethyl groups with semicarbazide in basic media proceed unequivocally to give pyrazolidine-1-carboxamides. The direction of the reactions of these enones with thiosemicarbazide depends on their structure; the reaction products are pyrazolidine- and 2-pyrazoline-1-carbothioamides. An enone containing a CF₃ group and an ethoxy group capable of replacement reacts with semicarbazide to give 2-pyrazoline-1-carboxamide and with thiosemicarbazide to give the double addition product, 5-(1-thiosemicarbazido)-2-pyrazoline-1-carbothiamide.

How to Cite
Sanin, A. V.; Nenaidenko, V. G.; Kuz'min, V. S.; Balenkova, E. S. Chem. Heterocycl. Compd. 1998, 34, 558. [Khim. Geterotsikl. Soedin. 1998, 34, 634.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF02290939