Synthesis and neurotropic properties of N-acylphenothiazines

Authors

  • Э. Лукевиц Latvian Institute of Organic Synthesis, Riga LV-1006
  • М. Трушуле Latvian Institute of Organic Synthesis, Riga LV-1006
  • C. Германе Latvian Institute of Organic Synthesis, Riga LV-1006
  • И. Тypoвский Latvian Institute of Organic Synthesis, Riga LV-1006

Abstract

N-Acylphenothiazines (derivatives of furan and phthalylamino acids) were synthesized, and their neurotropic properties were studied. It was established that the derivatives of phthalyl-ψ-aminobutyric acid increase the duration of hexenal narcosis (by 1.7 times) and increase the stimulant activity of phenamine (by 2.1 times). The glycine derivative prolongs the life of animals under the conditions of hypoxia by 77%.

How to Cite
Lukevics, E.; Trushule, M.; Germane, I.; Turovskii, I. Chem. Heterocycl. Compd. 1997, 33, 229. [Khim. Geterotsikl. Soedin. 1997, 265.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF02256765

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Published

1997-02-25

Issue

No. 2 (1997)

Section

Original Papers