Methods for the synthesis of 4-pyrazolyl- and 4-pyridyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-<i>b</i>]pyridines

Abstract

The most suitable method for the synthesis of 4-pyrazolyl- or 4-pyridyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridines uses 4-chloro- or 4-acetoxyacetoacetic esters in various versions of the Hantsch synthesis with closure of a lactone ring during the reaction. Some of the intermediate products (2-chloromethyl- and 2-acetoxymethyl-1,4-dihydropyridines) were isolated. Cyclization with the formation of lactones does not occur in N-substituted 1,4-dihydropyridines.

Как ссылаться
Sausln'sh, A.; Chekavlchus, B.; Duburs, G. Chem. Heterocycl. Compd. 1995, 31, 841. [Химия гетероцикл. соединений 1995, 966.]

Статья в английском издании журнала: DOI https://doi.org/10.1007/BF01170746