Synthesis of N-(ω-trimethylsilylalkyl)purines under conditions of interfacial catalysis

Abstract

A method of synthesis of N-(ω-trimethylsilylalkyl)purines, by alkylation of potassium salts of purine bases by 3-chloropropyltrimethylsilane and chloromethyltrimethylsilanes under conditions of interfacial catalysis, has been developed. Hydroxylation of the N-allyl group by dimethylphenylsilane, which is an alternative pathway of synthesis of silicon-containing purine derivatives, has been accomplished for the first time in the purine series. The structure of the compounds obtained was established by methods of PMR and UV spectroscopy.

How to Cite
Alksnis, É.; Lidak, M.; Lukevits, É. Chem. Heterocycl. Compd. 1995, 31, 577. [Khim. Geterotsikl. Soedin. 1995, 654.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF01166333