Chemistry of modified flavonoids. XVIII. Thiazole analogs of isoflavones. Homologous and isomeric series

Authors

  • Н. B. Горбуленко Taras Shevchenko Kiev University, Kiev 252601
  • А. В. Туров Taras Shevchenko Kiev University, Kiev 252601
  • B. П. Хиля Taras Shevchenko Kiev University, Kiev 252601

Abstract

Homologous and isomeric series of thiazole derivatives of isoflavones were produced on the basis of α-(4-methyl-2-thiazolyl)-2-hydroxyacetophenones. A study of α-(4-methyl-2-thiazoyl)-2-hydroxyacetophenones by PMR spectroscopy showed that these compounds exist in most nonpolar and low polarity organic solvents exclusively in the ketone form, but in dimethyl sulfoxide solution both the ketone and enol forms are observed in various ratios. A simple and effective preparative method of synthesis of homologs of 3-(2-diazolyl)chromones was developed, and their alkylation at the phenolic hydroxyl was studied. Data of biological tests of the compounds synthesized are presented.

How to Cite
Gorbulenko, N. V.; Turov, A. V.; Khilya, V. P. Chem. Heterocycl. Compd. 1995, 31, 441. [Khim. Geterotsikl. Soedin. 1995, 505.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF01177015

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Published

1995-04-25

Issue

No. 4 (1995)

Section

Original Papers