4-Hydroxy-2-quinolones. 23. N-(2-thiazolyl)amides of 1-R-2-oxo-4-hydroxyquinoline-3-carboxylic acids — A new group of potential antiinflammatory agents

Authors

  • И. В. Украинец Ukrainian Pharmaceutical Academy, Kharkov 310002
  • O. B. Горохова Ukrainian Pharmaceutical Academy, Kharkov 310002
  • C. Г. Таран Ukrainian Pharmaceutical Academy, Kharkov 310002
  • А. B. Туров Ukrainian Pharmaceutical Academy, Kharkov 310002

Abstract

By thermolysis of equimolar quantities of 1-R-2-oxo-3-carbethoxy-4-hydroxyquinolines and 2-aminothiazole in diphenyl oxide, we have synthesized N-(2-thiazolyl)amides of 1-R-2-oxo-4-hydroxyquinoline-3-carboxylic acids. some of the substances that were obtained have high antiexudative activity (carrageenan edema), higher than the activity of sudoxicam.

How to Cite
Ukrainets, I. V.; Gorokhova, O. V.; Taran, S. G.; Turov, A. V. Chem. Heterocycl. Compd. 1994, 30, 1211. [Khim. Geterotsikl. Soedin. 1994, 1397.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF01184887

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Published

1994-10-25

Issue

No. 10 (1994)

Section

Original Papers