Study of the characteristics of rearrangements of 5-amino-1,2,3-thiadiazole-4-carbothioamides

Authors

  • Ю. Ю. Моржерин Department of Organic Synthesis Technology, Urals State Technical University—UPI, Ekaterinburg 620002.
  • B. А. Бакулев Department of Organic Synthesis Technology, Urals State Technical University—UPI, Ekaterinburg 620002.
  • E. Ф. Данкова Department of Organic Synthesis Technology, Urals State Technical University—UPI, Ekaterinburg 620002.
  • B. C. Мокрушин Department of Organic Synthesis Technology, Urals State Technical University—UPI, Ekaterinburg 620002.

Abstract

Using NMR spectroscopy, we have determined the relative stability and the effect of the solvent on the ratio of isomeric N,N-disubstituted 5-amino-1,2,3-thiadiazole-4-carbothioamides in a mixture. We carried out chromatographic separation of a mixture of 5-benzylamino-1,2,3-thiadiazole-4-N-methylcarbothioamide and 5-methylamino-1,2,3-thiadiazole-4-N-benzylcarbothioamide and we show that when each compound dissolves, it rapidly isomerizes with formation of the initial composition. We conclude that the orientation of the rearrangement process is thermodynamically controlled.

How to Cite
Morzherin, Yu. Yu.; Bakulev, V. A.; Dankova, E. F.; Mokrushin, V. S. Chem. Heterocycl. Compd. 1994, 30, 483. [Khim. Geterotsikl. Soedin. 1994, 548.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF01169948

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Published

1994-04-25

Issue

No. 4 (1994)

Section

Original Papers