SYNTHESIS OF 5-(4-AMINOPHENYL)-2-(ARYLAMINO)-1,3,4-THIADIAZOLES AND THEIR SCHIFF BASE DERIVATIVES AS ANTIMYCOBACTERIAL AGENTS

Authors

  • K. A. Dilmaghani Urmia University
  • N. H. Jazani Urmia Medical Science University
  • F. Nasuhi Pur Urmia University
  • N. Shokoufeh Urmia University
  • F. Ghadiri Urmia University
  • F. M. Fakhraee Institute of Standard and Industrial Research of Iran

DOI:

https://doi.org/10.1007/1270

Keywords:

salicylaldehyde, 1, 3, 4-thiadiazole, in vitro, Mycobacterium smegmatis, Schiff base

Abstract

The condensation reaction of 5-(4-aminophenyl)-N-aryl-1,3,4-thiadiazol-2-ylamines with salicylaldehyde, 3-hydroxybenzaldehyde, 4-hydroxybenzaldehyde, 5-bromosalicylaldehyde, 5-chlorosalicylaldehyde, 4-methoxybenzaldehyde, 3-nitrobenzaldehyde and 4-nitrobenzaldehyde results in series of new Schiff bases. The synthesized compounds were tested for their antimicrobial efficiency against Mycobacterium smegmatis PTCC 1307 in vitro. All compounds showed significant antiproliferative activity against M. smegmatis.

Also published in Chemistry of Heterocyclic Compounds, 2012, 48 (2), pp 362-367

http://link.springer.com/article/10.1007/s10593-012-0998-y

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Published

2013-12-02

Issue

No. 2 (2012)

Section

Original Papers