REGIODIRECTED SYNTHESIS OF POLYFLUOROALKYLATED PYRIMIDO[1,2-<i>a</i>]BENZIMIDAZOLES

Authors

  • М. В. Горяева I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
  • Я. В. Бургарт I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
  • В. И. Салоутин I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
  • О. Н. Чупахин I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences

DOI:

https://doi.org/10.1007/1271

Keywords:

2-aminobenzimidazole, 2-ethoxymethylidene-3-oxo-3-polyfluoroalkylpropionate, pyrimido[1, 2-a]benzimidazole, condensation, regiodirection

Abstract

Conditions have been found for the regiodirected cyclization of 2-aminobenzimidazoles using ethyl 3-oxo-3-polyfluoroalkyl-2-ethoxymethylidenepropionates at the ethoxymethylidenefluoroacyl fragment to give ethyl pyrimidobenzimidazole-3-carboxylates.

Authors: M. V. Goryaeva, Ya. V. Burgart, V. I. Saloutin, and O. N. Chupakhin.

English translation in Chemistry of Heterocyclic Compounds, 2012, 48 (2), pp 372-376

http://link.springer.com/article/10.1007/s10593-012-1000-8

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Published

2013-12-02

Issue

No. 2 (2012)

Section

Original Papers