STUDY OF LACTAMS. VI. SYNTHESIS OF 6-SUBSTITUTED PURINO[8,9-1¹,2²]ISOINDOLINES

Abstract

It is shown with 1-ethoxyisoindolenine that the reaction of lactim ethers with α-amino-α-cyanoacetamide also extends to partly aromatized lactim ethers, although these react much less readily. Condensation of 1-ethoxyisoindolenine with α-amino-cyanoacetamide gives 4-carbamido-5-aminoimidazo[1, 2-1′, 2′]isoindoline, from which a new series of purinoisoindioline derivatives is synthesized.

Authors: R. G. Glushkov, O. Yu. Magidson.

English Translation in Chemistry of Heterocyclic Compounds, 1965, 1 (1), pp 57-59

http://link.springer.com/article/10.1007/BF01168921