4-HYDROXY-2-QUINOLONES. 197. THE SEARCH FOR NOVEL DIURETICS AMONGST HALO-SUBSTITUTED 6-HYDROXY- 2-METHYL-4-OXO-1,2-DIHYDRO-4<i>H</i>-PYRROLO- [3,2,1-<i>ij</i>]QUINOLINE-5-CARBOXYLIC ACID ANILIDES

Authors

  • И. В. Украинец National University of Pharmacy
  • Н. Ю. Голик National University of Pharmacy
  • А. Л. Шемчук National University of Pharmacy
  • О. И. Набока National University of Pharmacy
  • Ю. В. Воронина National University of Pharmacy
  • А. В. Туров Taras Shevchenko National University

DOI:

https://doi.org/10.1007/1482

Keywords:

anilides, 4-hydroxy-2-oxoquinoline-3-carboxylic acids, methylindoline, amidation, diuretic activity

Abstract

A targeted synthesis of a series of halo-substituted 6-hydroxy-2-methyl-4-oxo-1,2‑dihydro-4H-pyrrolo-[3,2,1-ij]quinoline-5-carboxylic acid anilides have been carried out. Peculiarites of the 1H NMR spectra and the results of investigating the diuretic activity of these compounds are discussed.

Authors: I. V. Ukrainets, N. Yu. Golik, A. L. Shemchuk, O. I. Naboka, Yu. V. Voronina, and A. V. Turov

English Translation in Chemistry of Heterocyclic Compounds, 2011, 47 (7), pp 826-832

http://link.springer.com/article/10.1007/s10593-011-0842-9

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Published

2014-01-17

Issue

No. 7 (2011)

Section

Original Papers