REACTIONS OF 5-(HET)ARYL-1-ETHYL-2(1<i>H</i>)-PYRAZINONES WITH TERMINAL ARYLACETYLENES PROMOTED BY MICROWAVE RADIATION

Abstract

The reaction of 5-(het)aryl-1-ethyl-2(1H)-pyrazinones with terminal arylacetylenes, leading to a mixture of two isomeric 4-aryl- and 5-aryl-substituted 2(1H)-pyridones has been investigated. The regioselectivity of this reaction has been shown on the basis of reaction mixtures study by chromato-mass spectrometry. A crystallographic investigation of the synthesized 2(1H)-pyridones and also a forecast of their potential biological activity have been carried out.

Authors: E. V. Verbitskiy, E. M. Cheprakova, P. A. Slepuhin, M. G. Pervova, M. A. Samorukova, O. N. Zabelina, G. L. Rusinov, and V. N.  Charushin

English translation in Chemistry of Heterocyclic Compounds, 2011, 47 (6), pp 710-718

http://link.springer.com/article/10.1007/s10593-011-0824-y