SYNTHESIS OF N<sup>6</sup>-SUBSTITUTED ADENINES FROM 3-METHYLXANTHINE

Authors

  • П. М. Кочергин Center for the Chemistry of Medicinals, All-Russia Chemico-pharmaceutical Scientific Research Institute, Moscow
  • Л. В. Персанова State Institute for Hematological and Medicinal Materials
  • Е. В. Александрова Zaporozhe State Medical University

DOI:

https://doi.org/10.1007/184

Keywords:

benzyladenine, dichlorobenzylpurine, substituted adenines, kinetin, methylxanthine

Abstract

A series of 6-arylalkyl(hetarylalkyl, cycloalkyl, carboxyalkyl)amino-7-benzyl-2-chloropurines have been synthesized from 3-methylxanthine via the reaction of the intermediate 7-benzyl-2,6-dichloropurine with amines and aminoacids. N6-benzyladenine, N6-(a-furfuryl)adenine (kinetin), and N-(purinyl)glycine have been obtained via the catalytic hydrogenation of 7-benzyl-6-benzyl(furfuryl, carboxymethyl)amino-2-chloropurines.

Authors: P. M. Kochergin, L. V. Persanova, and E. V. Aleksandrova.

English Translation in Chemistry of Heterocyclic Compounds, 2000, 36 (4), pp 455-458

http://link.springer.com/article/10.1007/BF02269545

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Published

2013-01-22

Issue

No. 4 (2000)

Section

Original Papers