BROMINATION OF AROMATIC RING OF TETRAHYDRO-1,5-BENZODIAZEPIN-2-ONES

Abstract

Novel mono- or dibromo-substituted tetrahydro-1,5-benzodiazepinones were obtained by direct bromination of the corresponding 2,3,4,5-tetrahydro-(1H)-1,5-benzodiazepin-2-ones and 5‑N‑alkyl (or formyl) derivatives with bromine. Substituent effects and the orientation of the entering groups in the bromination reaction are discussed.

Also published in Chemistry of Heterocyclic Compounds, 2000, 36 (6), pp 698-704

http://link.springer.com/article/10.1007/BF02297679