SYNTHESIS OF SPIRO DERIVATIVES OF 1,2,3-TRIAZOLO[5,1-<i>b</i>][1,3,4]THIADIAZINES AND BIOLOGICAL ACTIVITY THEREOF

Authors

  • Татьяна А. Калинина Ural Federal University named after the First Russian Prezident B. N. Yeltzin, 19 Mir St., Yekaterinburg 620002, Russia
  • Ольга A. Быстрых Ural Federal University named after the First Russian Prezident B. N. Yeltzin, 19 Mir St., Yekaterinburg 620002, Russia
  • Варвара А. Поздина Ural Federal University named after the First Russian Prezident B. N. Yeltzin, 19 Mir St., Yekaterinburg 620002, Russia
  • Татьяна В. Глухарева Ural Federal University named after the First Russian Prezident B. N. Yeltzin, 19 Mir St., Yekaterinburg 620002, Russia
  • Мария B. Улитко Institute of Medical Cell Technologies, 22а Karl Marks St., Yekaterinburg 620026, Russia
  • Юрий Ю. Моржерин Ural Federal University named after the First Russian Prezident B. N. Yeltzin, 19 Mir St., Yekaterinburg 620002, Russia

DOI:

https://doi.org/10.1007/2428

Keywords:

spirocyclic compounds, 1, 3, 4-thiadiazines, 2, 3-triazoles, continuous cell lines, cytotoxicity, dermal fibroblasts, Dimroth rearrangement, МТТ assay, proliferation

Abstract

3-Cyclopentylidene(cyclohexylidene)amino-3H-1,2,3-triazole-4-thiolates, formed via Dimroth rearrangement of 1,2,3-thiadiazolylhydrazones of cyclopentanone and cyclohexanone in the presence of triethylamine, reacted in situ with α-bromoacetophenones with the formation of spirocyclic 6,7-dihydro-5H-[1,2,3]triazolo[5,1-b][1,3,4]thiadiazines. The effect of the obtained compounds on the viability and proliferative activity of four lines of cell cultures was studied. The selective proliferative activity was determined.

How to Cite
Kalinina, T. A.; Bystrykh, O. A.; Pozdina, V. A.; Glukhareva, T. V.; Ulitko, M. V.; Morzherin, Yu. Yu. Chem. Heterocycl. Compd. 2015, 51, 589. [Khim. Geterotsikl. Soedin. 2015, 51, 589.]

For this article in the English edition see DOI 10.1007/s10593-015-1742-1

 

 

Author Biographies

Татьяна А. Калинина, Ural Federal University named after the First Russian Prezident B. N. Yeltzin, 19 Mir St., Yekaterinburg 620002, Russia

Татьяна Андреевна Калинина

Ольга A. Быстрых, Ural Federal University named after the First Russian Prezident B. N. Yeltzin, 19 Mir St., Yekaterinburg 620002, Russia

Ольга Александровна Быстрых

Варвара А. Поздина, Ural Federal University named after the First Russian Prezident B. N. Yeltzin, 19 Mir St., Yekaterinburg 620002, Russia

Варвара Александровна Поздина

Татьяна В. Глухарева, Ural Federal University named after the First Russian Prezident B. N. Yeltzin, 19 Mir St., Yekaterinburg 620002, Russia

Татьяна Владимировна Глухарева

Мария B. Улитко, Institute of Medical Cell Technologies, 22а Karl Marks St., Yekaterinburg 620026, Russia

Мария Валерьевна Улитко

Юрий Ю. Моржерин, Ural Federal University named after the First Russian Prezident B. N. Yeltzin, 19 Mir St., Yekaterinburg 620002, Russia

Юрий Юрьевич Моржерин

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Published

2015-06-26

Issue

Vol. 51 No. 6 (2015)

Section

Letters to the Editor