SYNTHESIS OF CONDENSED HETEROCYCLES CONTAINING A PYRIMIDO[5,4-e][1,3]-THIAZINE FRAGMENT

Abstract

The cyclocondensation of 4,6-dichloro-2-methylthiopyridine-5-carbaldehyde and heterocyclic thiones such as 1,2,4-triazole-5-thione, imidazolidine-2-thione, imidazole-2-thione, and 4,5-diphenylimidazole-2-thione in dimethylformamide gave tricyclic heterocycles containing a pyrimido[5,4-e][1,3]thiazine fragment. The reaction of 6-chloro-8-methylthio-5H-pyrimido[5,4-e][1,2,4]triazolo[5,1-b][1,3]thiazin-5-ol with diethylamine, pyrrolidine, and morpholine gave the corresponding 6-dialkylamino-pyrimidotriazolothiazines.

Authors: A. Brukshtus and S. Tumkevicius.

English Translation in Chemistry of Heterocyclic Compounds, 2000, 36 (6), pp 751-753

http://link.springer.com/article/10.1007/BF02297687