SYNTHESIS OF PURINE AND 2-AMINOPURINE CONJUGATES BEARING THE FRAGMENTS OF HETEROCYCLIC AMINES AT POSITION 6

Authors

  • Дмитрий А. Груздев I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22 S. Kovalevskoi / 20 Akademicheskaya St., Yekaterinburg 620990
  • Вера В. Мусияк I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22 S. Kovalevskoi / 20 Akademicheskaya St., Yekaterinburg 620990
  • Евгений Н. Чулаков I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22 S. Kovalevskoi / 20 Akademicheskaya St., Yekaterinburg 620990
  • Галина Л. Левит I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22 S. Kovalevskoi / 20 Akademicheskaya St., Yekaterinburg 620990
  • Виктор П. Краснов I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22 S. Kovalevskoi / 20 Akademicheskaya St., Yekaterinburg 620990

DOI:

https://doi.org/10.1007/2570

Keywords:

2-amino-6-chloropurine, 6-chloropurine, aromatic nucleophilic substitution, catalysis, heterocyclic amines

Abstract

A series of novel N-(purin-6-yl)- and N-(2-aminopurin-6-yl) derivatives of heterocyclic amines was synthesized. It was found that preferred preparative method for N-(purin-6-yl) derivatives of heterocyclic amines is interaction of 6-chloropurine with heterocyclic amines without any catalyst; whereas N-(2-aminopurin-6-yl) derivatives were obtained in the moderate-to-high yields while heating 2-amino-6-chloropurine and heterocyclic amines in water in the presence of sulfuric acid.

How to Cite
Gruzdev, D. A.; Musiyak, V. V.; Chulakov, E. N.; Levit, G. L.; Krasnov, V. P. Chem. Heterocycl. Compd. 2015, 51, 738. [Khim. Geterotsikl. Soedin. 2015, 51, 738.]

For this article in the English edition see DOI 10.1007/s10593-015-1767-5

Author Biographies

Дмитрий А. Груздев, I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22 S. Kovalevskoi / 20 Akademicheskaya St., Yekaterinburg 620990

Дмитрий Андреевич Груздев

Postovsky Institute of organic synthesis, Russian academy of sciences (Ural Branch)

Вера В. Мусияк, I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22 S. Kovalevskoi / 20 Akademicheskaya St., Yekaterinburg 620990

Вера Владимировна Мусияк

Postovsky Institute of organic synthesis, Russian academy of sciences (Ural Branch)

Евгений Н. Чулаков, I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22 S. Kovalevskoi / 20 Akademicheskaya St., Yekaterinburg 620990

Евгений Николаевич Чулаков

Postovsky Institute of organic synthesis, Russian academy of sciences (Ural Branch)

Галина Л. Левит, I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22 S. Kovalevskoi / 20 Akademicheskaya St., Yekaterinburg 620990

Галина Львовна Левит

Postovsky Institute of organic synthesis, Russian academy of sciences (Ural Branch)

Виктор П. Краснов, I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22 S. Kovalevskoi / 20 Akademicheskaya St., Yekaterinburg 620990

Виктор Павлович Краснов

Postovsky Institute of organic synthesis, Russian academy of sciences (Ural Branch)

Published

2015-08-28

Issue

Section

Original Papers