REACTIONS OF THEOPHYLLINES. CHEMICAL CONVERSIONS OF 8-AMINOTHEOPHYLLINATES

Abstract

Thermally stable, colored 8-aminotheophyllinates (betaine derivatives of theophylline) form unstable, colorless salts with strong mineral acids and undergo partial decomposition to a uric acid upon prolonged refluxing with concentrated base solution. Substituted 8-pyridinium theophyllinates readily take part in typical reactions of the functional group in the substituted pyridine ring with retention of the betaine structure. The formation of the synthesized compounds was confirmed by IR and NMR spectroscopy.

Authors: I. I. Kuz'menko and T. V. Zvolinskaya.

English Translation in Chemistry of Heterocyclic Compounds, 2000, 36 (8), pp 963-970

http://link.springer.com/article/10.1007/BF02256982