SYNTHESIS OF PYRIDO[2,3-b][1,4]BENZOXAZEPINES VIA A FRIEDEL−CRAFTS CYCLIZATION

Authors

  • S. Guo Center for Combinatorial Chemistry and Drug Discovery, School of Pharmaceutical Sciences Jilin University, 1266 Fujin Road, Changchun, Jilin 130021
  • X. Zhong Center for Combinatorial Chemistry and Drug Discovery, School of Pharmaceutical Sciences Jilin University, 1266 Fujin Road, Changchun, Jilin 130021
  • B. Gong Center for Combinatorial Chemistry and Drug Discovery, School of Pharmaceutical Sciences Jilin University, 1266 Fujin Road, Changchun, Jilin 130021
  • H. Cui Center for Combinatorial Chemistry and Drug Discovery, School of Pharmaceutical Sciences Jilin University, 1266 Fujin Road, Changchun, Jilin 130021
  • J. Xiang Center for Combinatorial Chemistry and Drug Discovery, School of Pharmaceutical Sciences Jilin University, 1266 Fujin Road, Changchun, Jilin 130021

DOI:

https://doi.org/10.1007/3140

Keywords:

2-phenoxypyridin-3-amine, pyrido[2, 3-b][1, 4]benzoxazepine, tricyclic compounds, Friedel−Crafts cyclization

Abstract

An efficient and practical method has been developed for the synthesis of 6-aryl-substituted pyrido[2,3-b][1,4]benzoxazepines via a Friedel−Crafts reaction of readily accessible 2-phenoxypyridin-3-amines and aromatic acids.

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Published

2016-06-09

Issue

Vol. 52 No. 5 (2016)

Section

Original Papers