SYNTHESIS OF BENZO[4,5]IMIDAZO[2,1-A]ISOQUINOLINES VIA INTRAMOLECULAR C-H BOND FUNCTIONALIZATION

Abstract

The preparationof benzo[4,5]imidazo[2,1-a]isoquinolines has been achieved using  PdCl2/PPh3 as catalyst.This protocol has such followingadvantages as simple sequential work-up, good selectivity and toleranceuniversality for functional groups. A wide range of (Z)-2-bromovinylamines, andwith-drawing or electron-donating 2-chlorophenylboronic acids were able to undergo sequentialprocess smoothly to generate the corresponding benzo[4,5]imidazo[2,1-a]isoquinolines products with the yield 62~77%.