AMINOMETHYLATION OF GUARESCHI IMIDES: SYNTHESIS OF 2,4-DIOXO-1<i>H</i>,5<i>H</i>-3,7-SPIRO[DIAZABICYCLO[3.3.1]NONANE-9,4'- PIPERIDINE]-1,5-DICARBONITRILES

Authors

  • Анастасия Н. Хрусталева Kuban State University, 149 Stavropol'skaya St., Krasnodar 350040
  • Константин А. Фролов Kuban State University, 149 Stavropol'skaya St., Krasnodar 350040
  • Виктор В. Доценко Kuban State University, 149 Stavropol'skaya St., Krasnodar 350040
  • Николай A. Аксенов North Caucasus Federal University, 1A Pushkin St., Stavropol 355009
  • Инна B. Аксенова North Caucasus Federal University, 1A Pushkin St., Stavropol 355009
  • Сергей Г. Кривоколыско Kuban State University, 149 Stavropol'skaya St., Krasnodar 350040

DOI:

https://doi.org/10.1007/3707

Keywords:

bispidines, 3, 7-diazabicyclo[3.3.1]nonanes, 9-diazaspiro[5.5]undecane, 2, 6-dioxopiperidine-3, 5-dicarbonitrile, Guareschi imides, aminomethylation, Mannich reaction

Abstract

The aminomethylation reaction of 9-benzyl-2,4-dioxo-3,9-diazaspiro[5.5]undecane-1,5-dicarbonitrile hydrochloride in the presence of primary aliphatic amines and an excess of 37% aqueous formaldehyde led to the formation of 7-substituted 1'-benzyl-2,4-dioxo-1H,5H-spiro[3,7-diazabicyclo[3.3.1]nonane-9,4'-piperidine]-1,5-dicarbonitrile derivatives.

Authors: Anastasiya N. Khrustaleva*, Konstantin A. Frolov, Victor V. Dotsenko, Nikolai A. Aksenov, Inna V. Aksenova, Sergey G. Krivokolysko

Author Biographies

Анастасия Н. Хрусталева, Kuban State University, 149 Stavropol'skaya St., Krasnodar 350040

кафедра физики и химии

Константин А. Фролов, Kuban State University, 149 Stavropol'skaya St., Krasnodar 350040

кафедра физики и химии

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Published

2017-10-03

Issue

Vol. 53 No. 8 (2017)

Section

Original Papers