SYNTHESIS AND ANTIPROLIFERATIVE ACTIVITY OF NOVEL AMINOALKYLATED FLAVONES

Authors

  • Lili Yan College of Chemistry and Chemical Engineering, Hunan University
  • Haoran Liu College of Chemistry and Chemical Engineering, Hunan University
  • Qiuan Wang College of Chemistry and Chemical Engineering, Hunan University
  • Gangqiang Wang School of Nuclear Technology and Chemistry & Biology, Hubei University of Science and Technology

DOI:

https://doi.org/10.1007/3873

Keywords:

5-hydroxy-4', 7-dimethoxyflavone, aminoalkylated flavones, antiproliferative activity, cancer cells, synthesis

Abstract

Naturally occurring 5-hydroxy-4',7-dimethoxyflavone (acacetin-7-O-methyl ether) was synthesized through dehydrogenation, glycoside hydrolysis, and selective O-methylation, using naringin as starting material. Two series of sixteen novel aminoalkylated flavones were synthesized from 5-hydroxy-4',7-dimethoxyflavone. Furthermore, antiproliferative activity of the compounds was evaluated in vitro on a panel of three human cancer cell lines (HeLa, HCC1954, and SK-OV-3) using Cell Counting Kit-8 assay. The result showed that most of the synthetic compounds exhibited moderate to potent antiproliferative activities against the three human cancer cell lines with IC50 values of 6.95–64.50 μΜ.

Author Biographies

Lili Yan, College of Chemistry and Chemical Engineering, Hunan University

master, College of Chemistry and Chemical Engineering, Hunan University

Haoran Liu, College of Chemistry and Chemical Engineering, Hunan University

doctor, College of Chemistry and Chemical Engineering, Hunan University

Qiuan Wang, College of Chemistry and Chemical Engineering, Hunan University

Professor, College of Chemistry and Chemical Engineering, Hunan University

Gangqiang Wang, School of Nuclear Technology and Chemistry & Biology, Hubei University of Science and Technology

doctor, School of Nuclear Technology and Chemistry & Biology, Hubei University of Science and Technology

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Published

2017-10-02

Issue

Vol. 53 No. 8 (2017)

Section

Original Papers