NONCATALYTIC DESTRUCTION OF 5-ACYLCOMANIC ACID ESTERS IN THE PRESENCE OF 2-METHYLINDOLES AS A NEW METHOD FOR THE SYNTHESIS OF INDOLYLCHALCONES

Abstract

Ethyl esters of 5-acylcomanic acids reacted with 2-methylindoles in 3:1 propanol–water mixture in the absence of catalyst, resulting in pyrone ring opening and destruction of the molecular framework and leading to trans-indolylchalcones in 52–70% yields.

Dmitrii L. Obydennov*, Ekaterina O. Pan’kina, Vyacheslav Ya. Sosnovskikh