THE ADDITION OF Β-KETOACIDS TO 4-(TRIFLUOROMETHYL)PYRIMIDIN- 2(1<i>Н</i>)-ONES WITH DECARBOXYLATION: AN EFFECTIVE METHOD FOR THE SYNTHESIS OF 4-(2-OXOALKYL)-6-(TRIFLUOROMETHYL)-3,4-DIHYDROPYRIMIDIN-2-ONES
DOI:
https://doi.org/10.1007/3995Keywords:
β-ketoacids, 4-(2-oxoalkyl)-6-(trifluoromethyl)-3, 4-dihydropyrimidin-2-ones, 4-(trifluoromethyl)pyrimidin-2(1Н)-ones, Michael addition.Abstract
β-Ketoacids reacted with 4-(trifluoromethyl)pyrimidin-2(1Н)-ones according to the mechanism of Michael addition–decarboxylation, forming 4-(2-oxoalkyl)-6-(trifluoromethyl)-3,4-dihydropyrimidin-2-ones.