7-ALKYLAMINO-6-NITROTETRAZOLO[1,5-<i>a</i>]PYRIMIDINES AS PRECURSORS OF ANOMALOUS NUCLEOSIDES AND HETEROCYCLES WITH POTENTIAL ANTISEPTIC ACTIVITY

Authors

  • Константин В. Саватеев Ural Federal University named after the first President of Russia B. N. Yeltsin, 19 Mira St., Yekaterinburg 620002
  • Виктор В. Федотов Ural Federal University named after the first President of Russia B. N. Yeltsin, 19 Mira St., Yekaterinburg 620002
  • Евгений Н. Уломский Ural Federal University named after the first President of Russia B. N. Yeltsin, 19 Mira St., Yekaterinburg 620002
  • Владимир Л. Русинов Ural Federal University named after the first President of Russia B. N. Yeltsin, 19 Mira St., Yekaterinburg 620002

DOI:

https://doi.org/10.1007/4209

Keywords:

tetrazolopyrimidines, adenosine receptors, azide-tetrazole tautomerism, chlorodeoxygenation, sepsis

Abstract

A method was developed for the synthesis of 7-alkylamino-5-methyl-6-nitrotetrazolo[1,5-a]pyrimidines from the readily available 5-methyl-6-nitrotetrazolo[1,5-a]pyrimidin-7(4H)-one by using a sequence of chlorodeoxygenation and amination reactions. The chlorinated intermediate formed along this route was isolated and characterized as 7-chloro-5-methyl-6-nitrotetrazolo[1,5-a]pyrimidine.

Authors: Konstantin V. Savateev*, Victor V. Fedotov, Eugeny N. Ulomskiy, Vladimir L. Rusinov

Downloads

Published

2018-03-27

Issue

Vol. 54 No. 2 (2018)

Section

Original Papers