A STUDY OF PLANT COUMARINS. 16. SYNTHESIS AND TRANSFORMATIONS OF 7-ALKYNYLCOUMARINS

Authors

  • Алла В. Липеева N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 Akademika Lavrentieva Ave., Novosibirsk 630090
  • Эльвира Э. Шульц N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 Akademika Lavrentieva Ave., Novosibirsk 630090 Novosibirsk National Research State University, 2 Pirogova St., Novosibirsk 630090

DOI:

https://doi.org/10.1007/4232

Keywords:

arylalkynes, coumarins, 1, 2, 3-triazoles, CuААС reaction, Sonogashira reaction

Abstract

7-Alkynyl-substituted coumarins were synthesized by a Sonogashira reaction of 6-substituted 7-(trifluoromethylsulfonyloxy)coumarins with terminal acetylenes. The reaction of 7-ethynyl-substituted coumarins with azidobenzoic acids in the presence of copper(II) sulfate and sodium ascorbate was used to synthesize the respective 7-[(1-carboxyphenyl)-1H-1,2,3-triazol-4-yl]coumarins.

Authors: Alla V. Lipeeva, Elvira E. Shults*

Author Biographies

Алла В. Липеева, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 Akademika Lavrentieva Ave., Novosibirsk 630090

Научный сотрудник лаборатории медицинской химии НИОХ СО РАН

Эльвира Э. Шульц, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 Akademika Lavrentieva Ave., Novosibirsk 630090 Novosibirsk National Research State University, 2 Pirogova St., Novosibirsk 630090

зав. Лабораторией медицинской химии

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Published

2018-01-19

Issue

Vol. 53 No. 12 (2017)

Section

Original Papers