EFFICIENT SYNTHESIS OF SUBSTITUTED 8-(PYRAZOLO[3,4-<i>d</i>]PYRIMIDIN-6-YL)-1,2-DIHYDROQUINOLINES
DOI:
https://doi.org/10.1007/4639Keywords:
5-aminopyrazole-4-carbonitrile, pyrazolo[3, 4-d]pyrimidine, 8-(1Н-pyrazolo[3, 4-d]pyrimidin-6-yl)-1, 2-dihydroquinoline, pyrrolo[3, 2, 1-ij]quinoline-1, 2-dione, 4-trimethyl-1, hybrid moleculesAbstract
An effective method for the synthesis of 8-(1-aryl-4-methoxy-1Н-pyrazolo[3,4-d]pyrimidin-6-yl)-2,2,4-trimethyl-1,2-dihydroquinolines was developed on the basis of a three-component reaction between substituted 4,4,6-trimethyl-4H-pyrrolo[3,2,1-ij]quinoline-1,2-diones and 5-amino-1-aryl-1H-pyrazole-4-carbonitriles in refluxing methanol in the presence of an excess of sodium methoxide. HPLC-MS analysis showed that the cascade process started by addition of methanol molecule to the nitrile group of aminopyrazolecarbonitrile.
Authors: Svetlana M. Medvedeva, Yevgeniya A. Kosheleva, Mariya A. Berdnikova, Khidmet S. Shikhaliev*
