SYNTHESIS AND ANTIFUNGAL ACTIVITY OF 3-SUBSTITUTED 5-FERROCENYL-1<i>H</i>-PYRAZOLES

Authors

  • Man Ge Xi’an University of Architecture and Technology; Northwest University
  • Hailian Huang Northwest University
  • Xiaofeng Gou Northwest University
  • Chengwen Hua Northwest University
  • Bang Chen Northwest University
  • Junlong Zhao Northwest University

DOI:

https://doi.org/10.1007/4680

Keywords:

ferrocene, iron(III) phthalocyanine chloride, pyrazole, antifungal activity

Abstract

A convenient method for the selective synthesis of functionalized 3-substituted 5-ferrocenyl-1H-pyrazoles has been developed. Condensation reaction of α,β-unsaturated ferrocenyl ketones and tosylhydrazine in the presence of catalytic amount of iron(III) phthalocyanine chloride allowed to obtain nine new 3-substituted 5-ferrocenyl-1H-pyrazoles. The synthesized products were evaluated for their antifungal activity against Gibberella nicotiancola, Fusarium oxysporum f. sp. niveum, and Gibberella saubinetii. Most of the compounds exhibited excellent antifungal activity.

 

Author Biography

Man Ge, Xi’an University of Architecture and Technology; Northwest University

College of Science

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Published

2018-11-12

Issue

Vol. 54 No. 10 (2018)

Section

Original Papers