INVESTIGATIONS ON IMIDAZOLES. 99. SYNTHESIS AND SOME CONVERSIONS OF ESTERS OF 4- NITRO-5-IMIDAZOLYLMALONIC, -ACETOACETIC, AND -CYANOACETIC ACIDS

Abstract

Some esters of 1-alkyl(1,2-dialkyl)-4-nitro-5-imidazolylmalonic, -acetoacetic, and -cyanoacetic acids have been synthesized by the reaction of 5-chloro(bromo)-1-alkyl(1,2-dialkyl)-4-nitroimidazoles with ethyl esters of carboxylic acids indicated. Some conversions of the compounds obtained have been studied, including ketone and acid decomposition, synthesis of derivatives at the COOH and CO groups, and hydrogenation to 4-aminoimidazole derivatives.

Authors: P. M. Kochergin, L. A. Reznichenko, R. N. Gireva, and E. V. Aleksandrova.

English Translation in Chemistry of Heterocyclic Compounds, 1999, 35 (1), pp 51-57

http://link.springer.com/article/10.1007/BF02251661