4-(BOC-AMINO)-1<i>Н</i>-1,2,3-TRIAZOLE-5-CARBOXYLIC ACIDS – CONVENIENT REAGENTS FOR THE SYNTHESIS OF 1,4,6,7-TETRAHYDRO[1,2,3]TRIAZOLO[4,5-<i>e</i>][1,4]DIAZEPINE-5,8-DIONES

Authors

  • Наталия A. Сирота National University ''Kyiv-Mohyla Academy'', 2 Hrygorija Skorovody St., Kyiv 04655
  • Сергей B. Кемский Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St,, Kyiv 02094
  • Андрей B. Больбут Enamine Ltd., 78 Chervonotkatska St., Kyiv 02094
  • Михаил B. Вовк Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St,, Kyiv 02094

DOI:

https://doi.org/10.1007/5243

Keywords:

4-amino-1, 2, 3-triazole-5-carboxylic acids, ethyl [4-(Boc-amino)-1H-1, 3-triazole-5-carbonyl]glycinate, [1, 3]triazolo[4, 5-e][1, 4]diazepine, intramolecular cyclization

Abstract

The corresponding ethyl 5-carbonylglycinates were synthesized by condensation of 4-(Boc-amino)-1,2,3-triazole-5-carboxylic acids with ethyl glycinate hydrochloride. They were intramolecularly cyclized with the selective formation of 1,4,6,7-tetrahydro[1,2,3]triazolo[4,5-e][1,4]diazepine-5,8-diones.

Authors: Natalia А. Syrota*, Sergiy V. Kemskiy, Andriy V. Bol'but, Mikhailo V. Vovk

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Published

2019-11-12

Issue

Vol. 55 No. 11 (2019)

Section

Original Papers