SYNTHESIS OF POLYSUBSTITUTED PYRROLES BY THE REACTION OF ENAMINOKETONES, ARYLGLYOXALS, AND <i>N</i>,<i>N</i>-DIMETHYLBARBITURIC ACID

Authors

  • Надежда Н. Колос V. N. Karazin Kharkiv National University, 4 Svobody Sq., Kharkiv 61022, Ukraine
  • Наталия В. Чечина V. N. Karazin Kharkiv National University, 4 Svobody Sq., Kharkiv 61022, Ukraine

DOI:

https://doi.org/10.1007/5278

Keywords:

3-aminocrotonic acid ethyl ester, arylglyoxal hydrates, N, N-dimethylbarbituric acid, 3-[(4-oxopent-2-en-2-yl)amino]propanoic acid, polysubstituted pyrroles, domino reactions.

Abstract

Novel pentasubstituted pyrroles containing a propanoic acid fragment in position 1 were obtained by the reaction of arylglyoxals, N,Ndimethylbarbituric and 3-[(4-oxopent-2-en-2-yl)amino]propanoic acids both by sequential introduction of reagents and the one-pot method. The three-component condensation of phenylglyoxal, N,N-dimethylbarbituric acid, and 3-aminocrotonate afforded 3-carboxyethyl-2-methyl-5-phenylpyrrole with a pyrimidine fragment in position 4.

Author Biographies

Надежда Н. Колос, V. N. Karazin Kharkiv National University, 4 Svobody Sq., Kharkiv 61022, Ukraine

кафедра органической химии, профессор

Наталия В. Чечина, V. N. Karazin Kharkiv National University, 4 Svobody Sq., Kharkiv 61022, Ukraine

кафедра органической химии, аспирант

Published

2019-12-18

Issue

Section

Short Communications