SYNTHESIS OF POLYSUBSTITUTED PYRROLES BY THE REACTION OF ENAMINOKETONES, ARYLGLYOXALS, AND <i>N</i>,<i>N</i>-DIMETHYLBARBITURIC ACID
DOI:
https://doi.org/10.1007/5278Keywords:
3-aminocrotonic acid ethyl ester, arylglyoxal hydrates, N, N-dimethylbarbituric acid, 3-[(4-oxopent-2-en-2-yl)amino]propanoic acid, polysubstituted pyrroles, domino reactions.Abstract
Novel pentasubstituted pyrroles containing a propanoic acid fragment in position 1 were obtained by the reaction of arylglyoxals, N,Ndimethylbarbituric and 3-[(4-oxopent-2-en-2-yl)amino]propanoic acids both by sequential introduction of reagents and the one-pot method. The three-component condensation of phenylglyoxal, N,N-dimethylbarbituric acid, and 3-aminocrotonate afforded 3-carboxyethyl-2-methyl-5-phenylpyrrole with a pyrimidine fragment in position 4.Downloads
Published
2019-12-18
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Section
Short Communications