A CONVENIENT METHOD OF SYNTHESIS OF 8-ACYL-2,3,6,7-TETRAHYDRO-5<i>Н</i>-[1,3]THIAZOLO[3,2-<i>c</i>]PYRIMIDIN-5-ONES

Authors

  • Мария Б. Литвинчук Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv 02094, Ukraine
  • Антон В. Бентя Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv 02094, Ukraine
  • Наталия Ю. Сливка Lesya Ukrainka Eastern European National University, 13 Voli Ave., Lutsk 43025, Ukraine
  • Эдуард Б. Русанов Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv 02094, Ukraine
  • Михаил В. Вовк Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv 02094, Ukraine

DOI:

https://doi.org/10.1007/5383

Keywords:

1-chlorobenzyl isocyanates, (1, 3-thiazolidin-2-ylidene)ketones, [1, 3]thiazolo[3, 2-c]pyrimidines, cyclocondensation.

Abstract

5-Substituted (1,3-thiazolidin-2-ylidene)ketones react regioselectively with 1-chlorobenzyl isocyanates under mild conditions to form diastereomeric 8-acyl-2,3,6,7-tetrahydro-5H-[1,3]thiazolo[3,2-c]pyrimidin-5-ones, the relative configuration of the chiral centers of which was determined by X-ray structural analysis.

 

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Published

2020-01-31

Issue

Vol. 56 No. 1 (2020)

Section

Original Papers