SYNTHESIS AND EVALUATION OF BIOLOGICAL ACTIVITY OF HOMODRIMANE SESQUITERPENOIDS BEARING 1,3,4-OXADIAZOLE OR 1,3,4-THIADIAZOLE UNITS

Authors

  • Lidia Lungu Institute of Chemistry, Laboratory of Chemistry of Natural and Biologically Active Compounds, 3 Academiei St., Chisinau MD-2028, Moldova
  • Alexandru Ciocarlan Institute of Chemistry, Laboratory of Chemistry of Natural and Biologically Active Compounds, 3 Academiei St., Chisinau MD-2028, Moldova
  • Crina Smigon Institute of Chemistry, Laboratory of Chemistry of Natural and Biologically Active Compounds, 3 Academiei St., Chisinau MD-2028, Moldova
  • Ilker Ozer Institute of Chemistry, Laboratory of Chemistry of Natural and Biologically Active Compounds, 3 Academiei St., Chisinau MD-2028, Moldova
  • Sergiu Shova Institute of Chemistry, Laboratory of Chemistry of Natural and Biologically Active Compounds, 3 Academiei St., Chisinau MD-2028, Moldova ''Petru Poni'' Institute of Macromolecular Chemistry, 41A Grigore Ghica Voda Alley, Iasi RO-700487, Romania
  • Iacob Gutu Moldova State University, 60 A. Mateevici St., Chisinau MD-2009, Moldova
  • Nicoleta Vornicu Metropolitan Center of Research T.A.B.O.R., 9 Closca St., Iasi RO-700066, Romania
  • Ionel Mangalagiu ''Alexandru Ioan Cuza'' University of Iasi, Faculty of Chemistry, 11 Carol Bd., Iasi RO-700506, Romania
  • Michele D'Ambrosio University of Trento, Bioorganic Chemistry Laboratory, 14 Via Sommarive, Trento 38123, Italy
  • Aculina Aricu Institute of Chemistry, Laboratory of Chemistry of Natural and Biologically Active Compounds, 3 Academiei St., Chisinau MD-2028, Moldova

DOI:

https://doi.org/10.1007/5464

Keywords:

homodrimane sesquiterpenoid, oxadiazole, thiadiazole, antibacterial activity, antifungal activity.

Abstract

Synthesis of novel (+)-sclareolide-based homodrimane sesquiterpenoids bearing 1,3,4-oxadiazole or 1,3,4-thiadiazole units has been reported. These terpeno-heterocyclic compounds demonstrate promising antifungal and antibacterial activities toward fungal species Aspergillus niger, Fusarium solani, Penicillium chrysogenum, Penicillium frequentans, and Alternaria alternata and bacteria strains Pseudomonas aeruginosa and Bacillus sp. with minimum inhibitory concentration at µg/ml level.

Author Biographies

Lidia Lungu, Institute of Chemistry, Laboratory of Chemistry of Natural and Biologically Active Compounds, 3 Academiei St., Chisinau MD-2028, Moldova

Laboratory “Chemistry of Natural and Biologically Active Compounds”

Alexandru Ciocarlan, Institute of Chemistry, Laboratory of Chemistry of Natural and Biologically Active Compounds, 3 Academiei St., Chisinau MD-2028, Moldova

Laboratory “Chemistry of Natural and Biologically Active Compounds”

Crina Smigon, Institute of Chemistry, Laboratory of Chemistry of Natural and Biologically Active Compounds, 3 Academiei St., Chisinau MD-2028, Moldova

Laboratory “Chemistry of Natural and Biologically Active Compounds”

Ilker Ozer, Institute of Chemistry, Laboratory of Chemistry of Natural and Biologically Active Compounds, 3 Academiei St., Chisinau MD-2028, Moldova

Laboratory “Chemistry of Natural and Biologically Active Compounds”

Ionel Mangalagiu, ''Alexandru Ioan Cuza'' University of Iasi, Faculty of Chemistry, 11 Carol Bd., Iasi RO-700506, Romania

Faculty of Chemistry

Michele D'Ambrosio, University of Trento, Bioorganic Chemistry Laboratory, 14 Via Sommarive, Trento 38123, Italy

Laboratory of Bioorganic Chemistry

Aculina Aricu, Institute of Chemistry, Laboratory of Chemistry of Natural and Biologically Active Compounds, 3 Academiei St., Chisinau MD-2028, Moldova

Laboratory “Chemistry of Natural and Biologically Active Compounds”

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Published

2020-05-28

Issue

Vol. 56 No. 5 (2020)

Section

Original Papers