RECENT ADVANCES IN THE C(1)-FUNCTIONALIZATION OF TETRAHYDROISOQUINOLINES <i>via</i> MULTICOMPONENT REACTIONS

Authors

  • Pavneet Kaur Laboratory of Organic Chemistry, Department of Chemistry, Central University of Punjab, Bathinda 151001
  • Rakesh Kumar Laboratory of Organic Chemistry, Department of Chemistry, Central University of Punjab, Bathinda 151001

DOI:

https://doi.org/10.1007/5475

Keywords:

heterocyclic compounds, iminium ion, tetrahydroisoquinoline, C(1)-functionalization, multicomponent reactions

Abstract

1,2,3,4-Tetrahydroisoquinoline is an important structural motif of various natural products and therapeutic lead compounds. In recent years, considerable research interest has been witnessed toward synthesis of its C(1)-substituted derivatives, since they can act as precursors for various alkaloids displaying multifarious biological activities. This minireview offers short and non-exhaustive epitome of various multicomponent reactions for the C(1)-functionalization of 1,2,3,4-tetrahydroisoquinolines. In particular, reactions involving isomerization of iminium intermediate (exo/endo isomerization) are highlighted for the period of 2013–2019.

Author Biography

Rakesh Kumar, Laboratory of Organic Chemistry, Department of Chemistry, Central University of Punjab, Bathinda 151001

Assistant Professor

Department of Chemical Sciences, School of Basic and Applied Sciences,

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Published

2020-04-30

Issue

Vol. 56 No. 4 (2020): Green chemistry of heterocycles

Section

Review Articles