ENANTIOSELECTIVE SYNTHESIS OF 4,5-DISUBSTITUTED PYRROLIDIN-2-ONE DERIVATIVES WITH TWO STEREOCENTERS ON THE BASIS OF MICHAEL ADDUCTS
DOI:
https://doi.org/10.1007/5586Keywords:
chiral Mg2 , Ni2 , and Co2 complexes, 4, 5-disubstituted pyrrolidin-2-ones, Michael adduct, asymmetric catalysisAbstract
The addition of malonates to trans-β-alkyl-β-nitrostyrenes in the presence of chiral Mg2+ bisoxazoline complex and Ni2+ and Co2+ bis((S,S)- or (R,R)-N,N'-dibenzylcyclohexane-1,2-diamine) complexes resulted in the formation of Michael adducts with two stereocenters which were used as key precursors for the preparation of potentially biologically active enantiopure 4,5-disubstituted pyrrolidin-2-one derivatives.
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Published
2020-09-17
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Original Papers