ION EXCHANGE RESIN-CATALYZED SYNTHESIS OF BRIDGED TETRAOXANES POSSESSING <i>IN VITRO</i> CYTOTOXICITY AGAINST HELA CANCER CELLS

Authors

  • Vera A. Vil' N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, Moscow 119991, Russian Federation.
  • Ivan A. Yaremenko N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, Moscow 119991, Russian Federation.
  • Dmitri I. Fomenkov N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, Moscow 119991, Russian Federation
  • Dmitri O. Levitsky Mechanism and regulation of DNA repair team Université de Nantes, UFIP CNRS UMR 6286, 2 rue de la Houssinière, Nantes 44322, France
  • Fabrice Fleury Mechanism and regulation of DNA repair team Université de Nantes, UFIP CNRS UMR 6286, 2 rue de la Houssinière, Nantes 44322, France
  • Alexander O. Terent'ev N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, Moscow 119991, Russian Federation

DOI:

https://doi.org/10.1007/5618

Keywords:

peroxides, tetraoxanes, anticancer activity, heterogeneous catalysis, ion exchange resin, peroxidation.

Abstract

Bridged 1,2,4,5-tetraoxanes were prepared using available acidic ion exchange resin with high yields despite the possibility of peroxide decomposition under heterogeneous conditions. The bridged tetraoxanes demonstrated high cytotoxicity against HeLa cancer cells in vitro, which in some cases was higher than that of cisplatin, artesunate, and dihydroartemisinin.

Author Biographies

Vera A. Vil', N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, Moscow 119991, Russian Federation.

Dr., researcher at the N. D. Zelinsky Institute of Organic Chemistry

Ivan A. Yaremenko, N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, Moscow 119991, Russian Federation.

Dr., senior researcher at the N. D. Zelinsky Institute of Organic Chemistry

Alexander O. Terent'ev, N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, Moscow 119991, Russian Federation

Dr.sci., Prof. RAS, Corresponding Member of RAS,Deputy Director of N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences.Chief of Laboratory in N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Scienceshttp://peroxide.ucoz.org/Prof. in D.I. Mendeleev University of Chemical Technology of RussiaDirector of Higher Chemical College RASChief of Laboratory in All-Russian Research Institute for PhytopathologyDeputy Editor-in-chief, Journal "Russian Chemical Bulletin"http://www.russchembull.ru/rus/Editor-in-chiefJournal "Chemistry of Heterocyclic Compounds"Latvian Institute of Organic SynthesisRiga, LV-1006, Latviahttp://hgs.osi.lv/index.php/hgs

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Published

2020-07-10

Issue

Vol. 56 No. 6 (2020): Heterocyclic сompounds in medicinal chemistry

Section

Original Papers