PARALLEL SYNTHESIS OF DERIVATIVES OF 1<i>H</i>-1,2,4-TRIAZOLE-3-CARBOXYLIC ACIDS WITH HETEROCYCLIC SUBSTITUENTS AT POSITION 5

Authors

  • Любовь Е. Гребенкина MIREA – Russian Technological University, Institute of Fine Chemical Technologies named after M. V. Lomonosov, 78 Vernadskogo Ave., Moscow 11945
  • Андрей В. Матвеев MIREA – Russian Technological University, Institute of Fine Chemical Technologies named after M. V. Lomonosov, 78 Vernadskogo Ave., Moscow 11945
  • Михаил В. Чудинов MIREA – Russian Technological University, Institute of Fine Chemical Technologies named after M. V. Lomonosov, 78 Vernadskogo Ave., Moscow 11945

DOI:

https://doi.org/10.1007/5625

Keywords:

β-N-Boc-oxalamidrazone, 1, 2, 4-triazole-3-carboxamide, 4-triazole-3-carboxylic acids, cyclization, parallel synthesis

Abstract

A mild universal method for the synthesis of derivatives of 5-substituted 1H-1,2,4-triazole-3-carboxylic acids from a single precursor, ethyl β-N-Boc-oxalamidrazone, has been proposed. The method was applied for the parallel synthesis of a library of 1H-1,2,4-triazole-3-carboxamides with heterocyclic substituents at position 5.

Authors: Lyubov E. Grebenkina, Andrey V. Matveev*, Mikhail V. Chudinov

Author Biography

Андрей В. Матвеев, MIREA – Russian Technological University, Institute of Fine Chemical Technologies named after M. V. Lomonosov, 78 Vernadskogo Ave., Moscow 11945

к.х.н., доцент кафедры биотехнологии и промышленной фармации Института тонких химических технологий им. М.В. Ломоносова МИРЭА – Российского технологического университета

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Published

2020-10-14

Issue

Vol. 56 No. 9 (2020)

Section

Original Papers