NUCLEOPHILIC SUBSTITUTION OF THE NITRO GROUP IN 1-SUBSTITUTED 3-NITRO-1<i>H</i>-1,2,4-TRIAZOLES IN ETHANOLIC POTASSIUM HYDROXIDE

Authors

  • Ани Г. Асратян Institute of Organic Chemistry of Scientific–Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia, 26 Azatutyan Ave., Yerevan 0014, Armenia
  • Астхик А. Сукоян Institute of Organic Chemistry of Scientific–Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia, 26 Azatutyan Ave., Yerevan 0014, Armenia
  • Алексан Г. Шахатуни Molecular Structure Research Center of Scientific–Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia, 26 Azatutyan Ave., Yerevan 0014, Armenia
  • Геворг Г. Данагулян Institute of Organic Chemistry of Scientific–Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia, 26 Azatutyan Ave., Yerevan 0014, Armenia Russian-Armenian University, 123 Hovsep Emin St., Yerevan 0051, Armenia
  • Оганес С. Аттарян Institute of Organic Chemistry of Scientific–Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia, 26 Azatutyan Ave., Yerevan 0014, Armenia Russian-Armenian University, 123 Hovsep Emin St., Yerevan 0051, Armenia

DOI:

https://doi.org/10.1007/5659

Keywords:

1, 2, 4-triazole, dehydrochlorination, ethanolic solutions, nitro group, nucleophilic substitution.

Abstract

Dehydrochlorination of 1-(2-chloroethyl)-3-nitro-1H-1,2,4-triazole in ethanolic potassium hydroxide is accompanied by nucleophilic substitution of the nitro group by the ethoxy group. The same nucleophilic exchange in 1-substituted 3-nitro-1H-1,2,4-triazoles occurs in methanol and n-propanol solutions of potassium hydroxide.

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Published

2020-09-17

Issue

Vol. 56 No. 8 (2020)

Section

Short Communications