ALKALOID-LIKE ANNULATED PYRANO[4,3-<i>b</i>]PYRROLES: ANTIVIRAL ACTIVITY AND HYDROLYSIS

Authors

  • Екатерина Е. Храмцова Perm State University, 15 Bukireva St., Perm 614990, Russia
  • Максим В. Дмитриев Perm State University, 15 Bukireva St., Perm 614990, Russia
  • Николай И. Бормотов State Research Center of Virology and Biotechnology ''Vector'', Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Koltsovo 630559, Novosibirsk Obl., Russia
  • Ольга А. Серова State Research Center of Virology and Biotechnology ''Vector'', Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Koltsovo 630559, Novosibirsk Obl., Russia
  • Лариса Н. Шишкина State Research Center of Virology and Biotechnology ''Vector'', Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Koltsovo 630559, Novosibirsk Obl., Russia
  • Андрей Н. Масливец Perm State University, 15 Bukireva St., Perm 614990, Russia

DOI:

https://doi.org/10.1007/6044

Keywords:

pyrano[4, 3-b]pyrroles, antiviral activity, hetero-Diels–Alder reaction, hydrolysis, orthopoxviruses.

Abstract

Alkaloid-like angular 6/6/5/6-annulated pyrano[4,3-b]pyrroles (pretazettine analogs) contain chemically labile groups that can react with water at room temperature. Their antiviral activity against Vaccinia virus and their tendency to hydrolysis were investigated. Compounds that were more resistant to hydrolysis exhibited the greatest antiviral activity.

Author Biographies

Екатерина Е. Храмцова, Perm State University, 15 Bukireva St., Perm 614990, Russia

доцент, старший научный сотрудник кафедры органической химии

Максим В. Дмитриев, Perm State University, 15 Bukireva St., Perm 614990, Russia

доцент кафедры органической химии

Николай И. Бормотов, State Research Center of Virology and Biotechnology ''Vector'', Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Koltsovo 630559, Novosibirsk Obl., Russia

заведующий лабораторией ФБУН «Государственный научный центр вирусологии и биотехнологии „Вектор“»

Ольга А. Серова, State Research Center of Virology and Biotechnology ''Vector'', Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Koltsovo 630559, Novosibirsk Obl., Russia

научный сотрудник ФБУН «Государственный научный центр вирусологии и биотехнологии „Вектор“»

Лариса Н. Шишкина, State Research Center of Virology and Biotechnology ''Vector'', Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Koltsovo 630559, Novosibirsk Obl., Russia

заведующий отделом ФБУН «Государственный научный центр вирусологии и биотехнологии „Вектор“»

Андрей Н. Масливец, Perm State University, 15 Bukireva St., Perm 614990, Russia

Заведующий кафедрой органической химии

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Published

2021-05-05

Issue

Vol. 57 No. 4 (2021): Heterocycles Against Viruses

Section

Original Papers