MICROBIOLOGICAL TRANSFORMATION OF PIPERIDINE AND PYRIDINE DERIVATIVES

Authors

  • Л. B. Модянова M. V. Lomonosov Moscow State University
  • M. P. Дудучава M. V. Lomonosov Moscow State University
  • H. Ф. Пискункова M. V. Lomonosov Moscow State University
  • Г. B. Гришина M. V. Lomonosov Moscow State University
  • П. Б. Терентьев M. V. Lomonosov Moscow State University
  • И. А. Паршиков M. V. Lomonosov Moscow State University

DOI:

https://doi.org/10.1007/612

Abstract

Optically active 2-(4-hydroxyphenylcarbamoyloxymethyl)-1-methyl-1,2,5,6-tetrahydropyridine is obtained on microbiological transformation of 1-methyl-2-(N-phenyl-carbamoyloxymethyl)-1,2,5,6-tetrahydropyridine with a growing culture of the fungus C. verticillata VKPM F-430. Transformation of 2-(2-phenylethyl)pyridine by a methanoxidating culture of Methylococcus occurs either by hydroxylation of the side chain or conversion of the substrate into N-oxide, depending on the process conditions.

Author: L. V. Modyanova, M. R. Duduchava, N. F. Piskunkova, G. V. Grishina, P. B. Terent'ev, and I. A. Parshikov.

English Translation in Chemistry of Heterocyclic Compounds, 1999, 35 (5), pp 580-586

http://link.springer.com/article/10.1007/BF02324642

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Published

2013-05-14

Issue

No. 5 (1999)

Section

Original Papers