4-HYDRO-2-QUINOLONES. 192. RELATIONSHIP OF STRUCTURE AND ANALGESIC ACTIVITY OF 4-AMINO-2-OXO-1,2-DIHYDROQUINOLINE-3-CARBOXYLIC ACIDS AND THEIR DERIVATIVES

Authors

  • Б. В. Украинец National University of Pharmacy, Kharkiv 61002
  • Е. В. Моспанова Institute of Chemical Technology, Vladimir Dal' Eastern Ukrainian National University, Rubizhne 93003
  • А. А. Давиденко N. I. Pirogov Vinnitsa National Medical University, Vinnitsa 21018
  • С. В. Шишкина Institute for Single Crystals, National Academy of Sciences of Ukraine, Kharkiv 61001

DOI:

https://doi.org/10.1007/6152

Keywords:

4-N-R-2-oxo-1, 2 dihydroquinoline-3-carboxylic acids, analgesic activity, X-ray diffraction crystallographic structural analysis

Abstract

Some 4-N-R-2-oxo-1,2-dihydroquinoline‑3-carboxylic acids and their derivatives were synthesized as close structural analogs of the highly‑active analgesic 4-benzylamino-2-oxo-1,2-dihydro-quinolinecarboxylic acid. Pharmacological testing showed that manifestation of an analgesic effect depends on the presence of a carboxylic group and benzyl fragment in these molecules.

How to Cite
Ukrainets, I. V.; Mospanova, E. V.; Davidenko, A. A.; Shishkina, S. V. Chem. Heterocycl. Compd. 2011, 46, 1371. [Khim. Geterotsikl. Soedin. 2010, 1690.]

For this article in the English edition see DOI 10.1007/s10593-011-0674-7

 

 

 

 

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Published

2021-02-12

Issue

No. 11 (2010)

Section

Original Papers