RING-CLOSURE REACTIONS OF FUNCTIONALIZED VINYL SULFONAMIDES

Authors

  • Alexey V. Dobrydnev Enamine Ltd., 78 Chervonotkatska St., Kyiv 02094, Ukraine Taras Shevchenko National University of Kyiv, 60 Volodymyrska St., Kyiv 01601, Ukraine
  • Taras V. Omelian Enamine Ltd., 78 Chervonotkatska St., Kyiv 02094, Ukraine Taras Shevchenko National University of Kyiv, 60 Volodymyrska St., Kyiv 01601, Ukraine

DOI:

https://doi.org/10.1007/6257

Keywords:

sulfonamides, heterocycles, cyclization

Abstract

Diversity-oriented synthesis embodied in a strategy of pairing vinyl sulfonamide moiety with other functional groups resulted in an array of skeletally diverse 5–8-membered sultams (cyclic sulfonamides) in the fewest possible steps. In particular, this strategy allows utilization of a number of cyclization protocols including intramolecular Michael, Diels–Alder, Heck, Pauson–Khand, Baylis–Hillman reactions, ring-closing metathesis (RCM) and others.

Author Biographies

Alexey V. Dobrydnev, Enamine Ltd., 78 Chervonotkatska St., Kyiv 02094, Ukraine Taras Shevchenko National University of Kyiv, 60 Volodymyrska St., Kyiv 01601, Ukraine

Faculty of Chemistry, Department of Organic Chemistry

Researcher

Taras V. Omelian, Enamine Ltd., 78 Chervonotkatska St., Kyiv 02094, Ukraine Taras Shevchenko National University of Kyiv, 60 Volodymyrska St., Kyiv 01601, Ukraine

Faculty of Chemistry, Department of Organic Chemistry

PhD student

Downloads

Published

2021-06-19

Issue

Vol. 57 No. 6 (2021)

Section

Heterocycles in Focus