SYNTHESIS AND FUNCTIONALIZATION OF THE 3-(1,3,4-OXADIAZOL-2-YL)-1H-INDOLES

Authors

  • С. Б. Алябьев Research Institute of Chemical Diversity, 141401 Khimki, Moscow Region
  • Д. В. Кравченко Research Institute of Chemical Diversity, 141401 Khimki, Moscow Region
  • А. В. Иващенко Research Institute of Chemical Diversity, 141401 Khimki, Moscow Region

DOI:

https://doi.org/10.1007/6570

Keywords:

3-(1, 3, 4-oxadiazol-2-yl)-1H-indoles, [3-(1, 4-oxadiazol-2-yl)-1H-indol-1-yl]acetic acids, orthoesters, amide library, intramolecular cyclization

Abstract

A modified method is proposed for the preparative synthesis of 3-(1,3,4-oxadiazol-2-yl)-1H-indoles in high
yield. We are the first to demonstrate the functionalization of this heterocyclic system by alkylation. In particular, syntheses are reported for [3-(1,3,4-oxadiazol-2-yl)-1H-indol-1-yl]acetic acids and their amide derivatives.

How to Cite
Alyab'ev, S. B.; Kravchenko, D. V.; Ivashchenko, A. V. Chem. Heterocycl. Compd. 2009, 45, 1270. [Khim. Geterotsikl. Soedin. 2009, 1580.]

For this article in the English edition see DOI 10.1007/s10593-010-0418-0

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Published

2022-02-10

Issue

No. 10 (2009)

Section

Original Papers