4-HYDROXY-2-QUINOLONES. 155. BIOREVERSIBLE CHEMICAL MODIFICATION OF CHINOXYCAINE AT THE TERTIARY AMINO GROUP AS A METHOD OF IMPROVING ITS PHARMACEUTICAL ACTIVITY

Authors

  • И. В. Украинец National University of Pharmacy, Kharkiv 61002
  • В. В. Кравцова National University of Pharmacy, Kharkiv 61002
  • А. А. Ткач National University of Pharmacy, Kharkiv 61002
  • В. Б. Рыбаков M. V. Lomonosov State University, Moscow 119899,

DOI:

https://doi.org/10.1007/6693

Keywords:

4-hydroxy-2-oxo-1, 2-dihydroquinoline-3-carboxamides, local anesthetics, prodrug, X-ray structural analysis

Abstract

There are discussed several variants of the chemical modification of the local anesthetic chinoxicaine at the tertiary amino group, initially in use as the hydrochloride. It was found that a significant improvement in its pharmaceutical properties can be achieved by exchange of the hydrogen chloride for an alternative salt forming acid component.

How to Cite
Ukrainets, I. V.; Kravtsova, V. V.; Tkach, A. A.; Rybakov, V. B.  Chem. Heterocycl. Compd. 2009, 45, 698. [Khim. Geterotsikl. Soedin. 2009, 875.]

For this article in the English edition see DOI 10.1007/s10593-009-0326-3


Downloads

Published

2022-03-24

Issue

No. 6 (2009)

Section

Original Papers