SYNTHESIS OF 6,7-DIHYDRO-5<i>H</i>-BENZO[<i>c</i>]-1,2,4-TRIAZOLO[3,4-<i>a</i>]AZEPINES AND 6,7-DIHYDRO-5<i>H</i>-BENZO[<i>c</i>]TETRAZOLO[5,1-<i>a</i>]AZEPINES

Authors

  • Владимир А. Глушков Institute of Technical Chemistry, Ural Branch of the Russian Academy of Sciences, 3 Akademika Koroleva St., Perm 614068 Perm State University, 15 Bukireva St., Perm 614990
  • Ксения А. Мошева Institute of Technical Chemistry, Ural Branch of the Russian Academy of Sciences, 3 Akademika Koroleva St., Perm 614068 Perm State University, 15 Bukireva St., Perm 614990
  • Марк М. Зайцев Perm State University, 15 Bukireva St., Perm 614990
  • Вера С. Пелых Perm State University, 15 Bukireva St., Perm 614990
  • Валерия И. Карасик Perm State University, 15 Bukireva St., Perm 614990
  • Александр И. Андреев Perm State University, 15 Bukireva St., Perm 614990
  • Максим В. Дмитриев Perm State University, 15 Bukireva St., Perm 614990

DOI:

https://doi.org/10.1007/6965

Keywords:

benzo[c]azepines, hetarylhydrazines, tetrazolo[5, 1-a]azepines, 1, 2, 4-triazolobenzo[3, 4-a]azepines

Abstract

Cyclization of 1-hydrazinyl-3,3-dimethyl-3,4-tetrahydro-5H-benzo[c]azepine with ethyl orthoformate gave 5,5-dimethyl-6,7-dihydro-5H-benzo[c]-1,2,4-triazolo[3,4-a]azepine, and its reaction with acetic acid afforded 3,5,5-trimethyl-9,10-dimethoxy-6,7-dihydro-5Н-benzo[c]-1,2,4-triazolo[3,4-a]azepine. Nitrosation of 1-hydrazino-3,3-dimethyl-3,4-tetrahydro-5H-benzo[c]azepine led to the formation of substituted 6,7-dihydro-5H-benzo[c]tetrazolo[5,1-a]azepines.

Authors: Vladimir A. Glushkov*, Kseniya A. Mosheva, Mark M. Zaitsev, Vera S. Pelykh, Valeriya I. Karasik, Alexander I. Andreev, Maksim V. Dmitriev

Author Biographies

Владимир А. Глушков, Institute of Technical Chemistry, Ural Branch of the Russian Academy of Sciences, 3 Akademika Koroleva St., Perm 614068 Perm State University, 15 Bukireva St., Perm 614990

доктор химических наук (2006), профессор кафедры биохимии и медицинской биотехнологии Пермского государственного национального исследовательского университета, старший научный сотрудник лаборатории биологически активных соединений ИТХ УрО РАН ПФИЦ

Ксения А. Мошева, Institute of Technical Chemistry, Ural Branch of the Russian Academy of Sciences, 3 Akademika Koroleva St., Perm 614068 Perm State University, 15 Bukireva St., Perm 614990

Post-graduate student of the laboratory of biologically active substances

Марк М. Зайцев, Perm State University, 15 Bukireva St., Perm 614990

Graduate student

Вера С. Пелых, Perm State University, 15 Bukireva St., Perm 614990

Student

Валерия И. Карасик, Perm State University, 15 Bukireva St., Perm 614990

Student

Александр И. Андреев, Perm State University, 15 Bukireva St., Perm 614990

Assosiate professor

Максим В. Дмитриев, Perm State University, 15 Bukireva St., Perm 614990

Assosiate professor

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Published

2022-12-20

Issue

Vol. 58 No. 12 (2022)

Section

Original Papers