SYNTHESIS AND ANTICANCER PROPERTIES OF 7α-CHLORO-3-METHYL-1,1-DIOXOCEPH-3-EM-4-CARBOXYLIC ACID ESTERS

Authors

  • М. Ворона Latvian Institute of Organic Synthesis, Riga LV-1006
  • Г. Вейнберг Latvian Institute of Organic Synthesis, Riga LV-1006
  • И. Шестакова Latvian Institute of Organic Synthesis, Riga LV-1006
  • И. Канепе Latvian Institute of Organic Synthesis, Riga LV-1006
  • И. Поторочина Latvian Institute of Organic Synthesis, Riga LV-1006
  • К. Диковская Latvian Institute of Organic Synthesis, Riga LV-1006
  • Р. Бокалдере Latvian Institute of Organic Synthesis, Riga LV-1006
  • М. Петрова Latvian Institute of Organic Synthesis, Riga LV-1006
  • Э. Лиепиньш Latvian Institute of Organic Synthesis, Riga LV-1006
  • Э. Лукевиц Latvian Institute of Organic Synthesis, Riga LV-1006

DOI:

https://doi.org/10.1007/7678

Keywords:

esters of 7α-chloro-3-methyl-2-dimethylaminomethylene-1, 1-dioxoceph-3-em-4-carboxylic acid, esters of 7α-chloro-3-methyl-1, cytotoxic activity

Abstract

The tert-butyl esters of 3-azidomethyl-, 3-isocyanatomethyl-, 3-chloromethyl-, and 3-p-nitrophenylvinyl-7α-chloro-1,1-dioxoceph-3-em-4-carboxylic acid, and also esters of 7α-chloro-3-methyl-1,1-dioxoceph-3-em-4-carboxylic acid, and  of  7α-chloro-3-methyl-2-dimethylaminomethylene-1,1-dioxoceph-3-em-4-carboxylic acid have been synthesized. Results of cytotoxic screening of these compounds in relation to cancer and normal cells in vitro are correlated and analyzed.

How to Cite
Vorona, M.; Veinberg, G.; Shestakova, I.; Kanepe, I.; Potorochina, I.; Dikovskaya, K.; Bokaldere, R.; Petrova, M.; Liepinsh, E.; Lukevics, E.  Chem. Heterocycl. Compd. 2007, 43, 207. [Khim. Geterotsikl. Soedin. 2007, 259.]

For this article in the English edition see DOI 10.1007/s10593-007-0033-x


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Published

2023-04-03

Issue

No. 2 (2007)

Section

Original Papers