PREPARATION OF 2-UNSUBSTITUTED 5-ARYL(HETARYL)-1-HYDROXY- 1<i>Н</i>-IMIDAZOLES FROM OF 4-ARYL(HETARYL)-1-HYDROXY-2,5-DIHYDRO- 1<i>Н</i>-IMIDAZOLE-2-CARBOXYLIC ACID 3-OXIDES

Authors

  • Elena B. Nikolaenkova N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 Akademika Lavrentieva Ave., Novosibirsk 630090
  • Stanislav Yu. Grishchenko N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 Akademika Lavrentieva Ave., Novosibirsk 630090
  • Tatyana V. Rybalova N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 Akademika Lavrentieva Ave., Novosibirsk 630090
  • Alexei Ya. Tikhonov N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 Akademika Lavrentieva Ave., Novosibirsk 630090

Keywords:

glyoxylic acid, hydroxyaminooximes, 1-hydroxy-2,5-dihydro-1Н-imidazole 3-oxides, 1-hydroxy-1Н-imidazoles

Abstract

Alkylaromatic 1-hydroxyamino-2-oximes reacted at the hydroxyamino group with glyoxylic acid hydrate, providing 4-aryl(hetaryl)-
1-hydroxy-2,5-dihydro-1Н-imidazole-2-carboxylic acid 3-oxides that were converted upon heating into 5-aryl(hetaryl)-1-hydroxy-1Н-
imidazoles containing a hydrogen atom at the heterocycle position 2.

Author Biographies

Elena B. Nikolaenkova, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 Akademika Lavrentieva Ave., Novosibirsk 630090

н.с. Лаборатории гетероциклических соединений

Alexei Ya. Tikhonov, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 Akademika Lavrentieva Ave., Novosibirsk 630090

д.х.н., доцент, г.н.с. Лаборатории гетероциклических соединений

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Published

2024-01-10

Issue

Vol. 59 No. 11/12 (2023)

Section

Original Papers