4-HYDROXY-2-QUINOLONES. 109. ALKYLATION OF 4-SUBSTITUTED ETHYL 2-OXO-1,2-DIHYDROQUINOLINE-3-CARBOXYLATES

Authors

  • И. В. Украинец National Pharmaceutical University, Kharkiv, 61002
  • Л. В. Сидоренко National Pharmaceutical University, Kharkiv, 61002
  • О. В. Горохова National Pharmaceutical University, Kharkiv, 61002
  • Н. Л. Березнякова National Pharmaceutical University, Kharkiv, 61002
  • С. В. Шишкина Institute for Scintillation Materials, Ukraine National Academy of Sciences, Kharkiv, 61001

DOI:

https://doi.org/10.1007/7772

Keywords:

2-oxo-1, 2-dihydroquinolines, 1H-quinolin-2-ones, alkylation, X-ray structural analysis

Abstract

The alkylation of the ethyl esters of 4-methyl, 4-chloro-, and 4-amino substituted 2-oxo-1,2-dihydroquinoline-3-carboxylic acid by ethyl iodide in the system DMF/K2CO3 has been studied. Features of the structure of the starting compounds  and their effect on the ratio of the N- and O-alkyl products formed are discussed.

How to Cite
Ukrainets, I. V.;  Sidorenko, L. V.;  Gorokhova, O. V.; Bereznyakova, N. L.; Shishkina, S. V.  Chem. Heterocycl. Compd. 2006, 42, 1296. [Khim. Geterotsikl. Soedin. 2006, 1502.]

For this article in the English edition see DOI 10.1007/s10593-006-0238-4


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Published

2023-05-03

Issue

No. 10 (2006)

Section

Original Papers