SYNTHESIS OF NOVEL N<sub>2</sub>-ADAMANTYL DERIVATIVES OF 2-AMINO-6-METHYL-4(3H)-PYRIMIDINONE AS POTENTIAL ACTIVATORS OF TUMOR NECROSIS FACTOR (T RELEASE

Authors

  • Б. С. Орлинсон Volgograd State Technical University, Volgograd 400131
  • Р. В. Брунилин Volgograd State Technical University, Volgograd 400131
  • М. Б. Навроцкий Volgograd State Technical University, Volgograd 400131
  • Е. Н. Савельев Volgograd State Technical University, Volgograd 400131
  • Г. А. Новикова Volgograd State Technical University, Volgograd 400131

DOI:

https://doi.org/10.1007/7783

Keywords:

(adamant-1-yl)alkylamines, 2-(adamant-1-yl)alkylamino-6-methyl-4(3H)-pyrimidinones, 2-(ethylsulfanyl)- 6-methyl-4(3H)-pyrimidinone, aminolysis

Abstract

A method has been developed for the synthesis of N2-adamantyl-2-amino-6-methyl-4(3H)-pyrimidinones based on the reaction of (adamant-1-yl)alkylamine with 2-(ethylsulfanyl)-6-methyl-4(3H)-pyrimidinone which can lead to the corresponding derivatives in which the exocyclic nitrogen atom and the adamantyl radical are separated by a hydrocarbon fragment.

How to Cite
Novakov, I. A.; Orlinson, B. S.; Brunilin, R. V.; Nawrozkij, M. B.; Savel'ev, E. N.; Novikova, G. A.  Chem. Heterocycl. Compd. 2006, 42, 1331. [Khim. Geterotsikl. Soedin. 2006, 1541.]

For this article in the English edition see DOI 10.1007/s10593-006-0243-7


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Published

2023-05-12

Issue

No. 10 (2006)

Section

Original Papers